diff --git a/src/protocols/rdp/channels/audio-input/audio-buffer.c b/src/protocols/rdp/channels/audio-input/audio-buffer.c
index 30513419..5e5a7259 100644
--- a/src/protocols/rdp/channels/audio-input/audio-buffer.c
+++ b/src/protocols/rdp/channels/audio-input/audio-buffer.c
@@ -31,9 +31,10 @@
 #include <stdint.h>
 #include <stdlib.h>
 
-guac_rdp_audio_buffer* guac_rdp_audio_buffer_alloc() {
+guac_rdp_audio_buffer* guac_rdp_audio_buffer_alloc(guac_client* client) {
     guac_rdp_audio_buffer* buffer = calloc(1, sizeof(guac_rdp_audio_buffer));
     pthread_mutex_init(&(buffer->lock), NULL);
+    buffer->client = client;
     return buffer;
 }
 
@@ -270,8 +271,8 @@ void guac_rdp_audio_buffer_write(guac_rdp_audio_buffer* audio_buffer,
 
             /* Only actually invoke if defined */
             if (audio_buffer->flush_handler)
-                audio_buffer->flush_handler(audio_buffer->packet,
-                        audio_buffer->bytes_written, audio_buffer->data);
+                audio_buffer->flush_handler(audio_buffer,
+                        audio_buffer->bytes_written);
 
             /* Reset buffer in all cases */
             audio_buffer->bytes_written = 0;
diff --git a/src/protocols/rdp/channels/audio-input/audio-buffer.h b/src/protocols/rdp/channels/audio-input/audio-buffer.h
index 32f7def8..b67f9fd5 100644
--- a/src/protocols/rdp/channels/audio-input/audio-buffer.h
+++ b/src/protocols/rdp/channels/audio-input/audio-buffer.h
@@ -24,24 +24,27 @@
 #include <guacamole/user.h>
 #include <pthread.h>
 
+/**
+ * A buffer of arbitrary audio data. Received audio data can be written to this
+ * buffer, and will automatically be flushed via a given handler once the
+ * internal buffer reaches capacity.
+ */
+typedef struct guac_rdp_audio_buffer guac_rdp_audio_buffer;
+
 /**
  * Handler which is invoked when a guac_rdp_audio_buffer's internal packet
  * buffer has reached capacity and must be flushed.
  *
- * @param buffer
- *     The buffer which needs to be flushed as an audio packet.
+ * @param audio_buffer
+ *     The guac_rdp_audio_buffer that has reached capacity and needs to be
+ *     flushed.
  *
  * @param length
  *     The number of bytes stored within the buffer. This is guaranteed to be
  *     identical to the packet_size value specified when the audio buffer was
  *     initialized.
- *
- * @param data
- *     The arbitrary data pointer provided when the audio buffer was
- *     initialized.
  */
-typedef void guac_rdp_audio_buffer_flush_handler(char* buffer, int length,
-        void* data);
+typedef void guac_rdp_audio_buffer_flush_handler(guac_rdp_audio_buffer* audio_buffer, int length);
 
 /**
  * A description of an arbitrary PCM audio format.
@@ -66,12 +69,7 @@ typedef struct guac_rdp_audio_format {
 
 } guac_rdp_audio_format;
 
-/**
- * A buffer of arbitrary audio data. Received audio data can be written to this
- * buffer, and will automatically be flushed via a given handler once the
- * internal buffer reaches capacity.
- */
-typedef struct guac_rdp_audio_buffer {
+struct guac_rdp_audio_buffer {
 
     /**
      * Lock which is acquired/released to ensure accesses to the audio buffer
@@ -79,6 +77,11 @@ typedef struct guac_rdp_audio_buffer {
      */
     pthread_mutex_t lock;
 
+    /**
+     * The guac_client instance handling the relevant RDP connection.
+     */
+    guac_client* client;
+
     /**
      * The user from which this audio buffer will receive data. If no user has
      * yet opened an associated audio stream, this will be NULL.
@@ -145,17 +148,20 @@ typedef struct guac_rdp_audio_buffer {
      */
     void* data;
 
-} guac_rdp_audio_buffer;
+};
 
 /**
  * Allocates a new audio buffer. The new audio buffer will ignore any received
  * data until guac_rdp_audio_buffer_begin() is invoked, and will resume
  * ignoring received data once guac_rdp_audio_buffer_end() is invoked.
  *
+ * @param client
+ *     The guac_client instance handling the relevant RDP connection.
+ *
  * @return
  *     A newly-allocated audio buffer.
  */
-guac_rdp_audio_buffer* guac_rdp_audio_buffer_alloc();
+guac_rdp_audio_buffer* guac_rdp_audio_buffer_alloc(guac_client* client);
 
 /**
  * Associates the given audio buffer with the underlying audio stream which
diff --git a/src/protocols/rdp/channels/cliprdr.c b/src/protocols/rdp/channels/cliprdr.c
index f5fe2d75..b0e3345e 100644
--- a/src/protocols/rdp/channels/cliprdr.c
+++ b/src/protocols/rdp/channels/cliprdr.c
@@ -76,6 +76,9 @@ static UINT guac_rdp_cliprdr_send_format_list(CliprdrClientContext* cliprdr) {
     guac_rdp_clipboard* clipboard = (guac_rdp_clipboard*) cliprdr->custom;
     assert(clipboard != NULL);
 
+    guac_client* client = clipboard->client;
+    guac_rdp_client* rdp_client = (guac_rdp_client*) client->data;
+
     /* We support CP-1252 and UTF-16 text */
     CLIPRDR_FORMAT_LIST format_list = {
         .msgType = CB_FORMAT_LIST,
@@ -86,10 +89,12 @@ static UINT guac_rdp_cliprdr_send_format_list(CliprdrClientContext* cliprdr) {
         .numFormats = 2
     };
 
-    guac_client_log(clipboard->client, GUAC_LOG_TRACE, "CLIPRDR: Sending "
-            "format list");
+    guac_client_log(client, GUAC_LOG_TRACE, "CLIPRDR: Sending format list");
 
-    return cliprdr->ClientFormatList(cliprdr, &format_list);
+    pthread_mutex_lock(&(rdp_client->message_lock));
+    int retval = cliprdr->ClientFormatList(cliprdr, &format_list);
+    pthread_mutex_unlock(&(rdp_client->message_lock));
+    return retval;
 
 }
 
@@ -107,6 +112,17 @@ static UINT guac_rdp_cliprdr_send_format_list(CliprdrClientContext* cliprdr) {
  */
 static UINT guac_rdp_cliprdr_send_capabilities(CliprdrClientContext* cliprdr) {
 
+    /* This function is only invoked within FreeRDP-specific handlers for
+     * CLIPRDR, which are not assigned, and thus not callable, until after the
+     * relevant guac_rdp_clipboard structure is allocated and associated with
+     * the CliprdrClientContext */
+    guac_rdp_clipboard* clipboard = (guac_rdp_clipboard*) cliprdr->custom;
+    assert(clipboard != NULL);
+
+    guac_client* client = clipboard->client;
+    guac_rdp_client* rdp_client = (guac_rdp_client*) client->data;
+
+    /* We support CP-1252 and UTF-16 text */
     CLIPRDR_GENERAL_CAPABILITY_SET cap_set = {
         .capabilitySetType = CB_CAPSTYPE_GENERAL, /* CLIPRDR specification requires that this is CB_CAPSTYPE_GENERAL, the only defined set type */
         .capabilitySetLength = 12, /* The size of the capability set within the PDU - for CB_CAPSTYPE_GENERAL, this is ALWAYS 12 bytes */
@@ -119,7 +135,11 @@ static UINT guac_rdp_cliprdr_send_capabilities(CliprdrClientContext* cliprdr) {
         .capabilitySets = (CLIPRDR_CAPABILITY_SET*) &cap_set
     };
 
-    return cliprdr->ClientCapabilities(cliprdr, &caps);
+    pthread_mutex_lock(&(rdp_client->message_lock));
+    int retval = cliprdr->ClientCapabilities(cliprdr, &caps);
+    pthread_mutex_unlock(&(rdp_client->message_lock));
+
+    return retval;
 
 }
 
@@ -190,6 +210,9 @@ static UINT guac_rdp_cliprdr_send_format_data_request(
     guac_rdp_clipboard* clipboard = (guac_rdp_clipboard*) cliprdr->custom;
     assert(clipboard != NULL);
 
+    guac_client* client = clipboard->client;
+    guac_rdp_client* rdp_client = (guac_rdp_client*) client->data;
+
     /* Create new data request */
     CLIPRDR_FORMAT_DATA_REQUEST data_request = {
         .requestedFormatId = format
@@ -199,11 +222,14 @@ static UINT guac_rdp_cliprdr_send_format_data_request(
      * data is received via a Format Data Response PDU */
     clipboard->requested_format = format;
 
-    guac_client_log(clipboard->client, GUAC_LOG_TRACE, "CLIPRDR: Sending "
-            "format data request.");
+    guac_client_log(client, GUAC_LOG_TRACE, "CLIPRDR: Sending format data request.");
 
     /* Send request */
-    return cliprdr->ClientFormatDataRequest(cliprdr, &data_request);
+    pthread_mutex_lock(&(rdp_client->message_lock));
+    int retval = cliprdr->ClientFormatDataRequest(cliprdr, &data_request);
+    pthread_mutex_unlock(&(rdp_client->message_lock));
+
+    return retval;
 
 }
 
@@ -265,15 +291,19 @@ static UINT guac_rdp_cliprdr_format_list(CliprdrClientContext* cliprdr,
     guac_rdp_clipboard* clipboard = (guac_rdp_clipboard*) cliprdr->custom;
     assert(clipboard != NULL);
 
-    guac_client_log(clipboard->client, GUAC_LOG_TRACE, "CLIPRDR: Received "
-            "format list.");
+    guac_client* client = clipboard->client;
+    guac_rdp_client* rdp_client = (guac_rdp_client*) client->data;
+
+    guac_client_log(client, GUAC_LOG_TRACE, "CLIPRDR: Received format list.");
 
     CLIPRDR_FORMAT_LIST_RESPONSE format_list_response = {
         .msgFlags = CB_RESPONSE_OK
     };
 
     /* Report successful processing of format list */
+    pthread_mutex_lock(&(rdp_client->message_lock));
     cliprdr->ClientFormatListResponse(cliprdr, &format_list_response);
+    pthread_mutex_unlock(&(rdp_client->message_lock));
 
     /* Prefer Unicode (in this case, UTF-16) */
     if (guac_rdp_cliprdr_format_supported(format_list, CF_UNICODETEXT))
@@ -284,9 +314,9 @@ static UINT guac_rdp_cliprdr_format_list(CliprdrClientContext* cliprdr,
         return guac_rdp_cliprdr_send_format_data_request(cliprdr, CF_TEXT);
 
     /* Ignore any unsupported data */
-    guac_client_log(clipboard->client, GUAC_LOG_DEBUG, "Ignoring unsupported "
-            "clipboard data. Only Unicode and text clipboard formats are "
-            "currently supported.");
+    guac_client_log(client, GUAC_LOG_DEBUG, "Ignoring unsupported clipboard "
+            "data. Only Unicode and text clipboard formats are currently "
+            "supported.");
 
     return CHANNEL_RC_OK;
 
@@ -320,8 +350,10 @@ static UINT guac_rdp_cliprdr_format_data_request(CliprdrClientContext* cliprdr,
     guac_rdp_clipboard* clipboard = (guac_rdp_clipboard*) cliprdr->custom;
     assert(clipboard != NULL);
 
-    guac_client_log(clipboard->client, GUAC_LOG_TRACE, "CLIPRDR: Received "
-            "format data request.");
+    guac_client* client = clipboard->client;
+    guac_rdp_client* rdp_client = (guac_rdp_client*) client->data;
+
+    guac_client_log(client, GUAC_LOG_TRACE, "CLIPRDR: Received format data request.");
 
     guac_iconv_write* writer;
     const char* input = clipboard->clipboard->buffer;
@@ -341,11 +373,11 @@ static UINT guac_rdp_cliprdr_format_data_request(CliprdrClientContext* cliprdr,
         /* Warn if clipboard data cannot be sent as intended due to a violation
          * of the CLIPRDR spec */
         default:
-            guac_client_log(clipboard->client, GUAC_LOG_WARNING, "Received "
-                    "clipboard data cannot be sent to the RDP server because "
-                    "the RDP server has requested a clipboard format which "
-                    "was not declared as available. This violates the "
-                    "specification for the CLIPRDR channel.");
+            guac_client_log(client, GUAC_LOG_WARNING, "Received clipboard "
+                    "data cannot be sent to the RDP server because the RDP "
+                    "server has requested a clipboard format which was not "
+                    "declared as available. This violates the specification "
+                    "for the CLIPRDR channel.");
             free(output);
             return CHANNEL_RC_OK;
 
@@ -363,10 +395,12 @@ static UINT guac_rdp_cliprdr_format_data_request(CliprdrClientContext* cliprdr,
         .msgFlags = CB_RESPONSE_OK
     };
 
-    guac_client_log(clipboard->client, GUAC_LOG_TRACE, "CLIPRDR: Sending "
-            "format data response.");
+    guac_client_log(client, GUAC_LOG_TRACE, "CLIPRDR: Sending format data response.");
 
+    pthread_mutex_lock(&(rdp_client->message_lock));
     UINT result = cliprdr->ClientFormatDataResponse(cliprdr, &data_response);
+    pthread_mutex_unlock(&(rdp_client->message_lock));
+
     free(start);
     return result;
 
@@ -407,9 +441,9 @@ static UINT guac_rdp_cliprdr_format_data_response(CliprdrClientContext* cliprdr,
 
     /* Ignore received data if copy has been disabled */
     if (settings->disable_copy) {
-        guac_client_log(clipboard->client, GUAC_LOG_DEBUG, "Ignoring received "
-                "clipboard data as copying from within the remote desktop has "
-                "been explicitly disabled.");
+        guac_client_log(client, GUAC_LOG_DEBUG, "Ignoring received clipboard "
+                "data as copying from within the remote desktop has been "
+                "explicitly disabled.");
         return CHANNEL_RC_OK;
     }
 
@@ -439,9 +473,8 @@ static UINT guac_rdp_cliprdr_format_data_response(CliprdrClientContext* cliprdr,
          * here. The values which may be stored within requested_format are
          * completely within our control. */
         default:
-            guac_client_log(clipboard->client, GUAC_LOG_DEBUG, "Requested "
-                    "clipboard data in unsupported format (0x%X).",
-                    clipboard->requested_format);
+            guac_client_log(client, GUAC_LOG_DEBUG, "Requested clipboard data "
+                    "in unsupported format (0x%X).", clipboard->requested_format);
             return CHANNEL_RC_OK;
 
     }
@@ -453,7 +486,7 @@ static UINT guac_rdp_cliprdr_format_data_response(CliprdrClientContext* cliprdr,
         int length = strnlen(received_data, sizeof(received_data));
         guac_common_clipboard_reset(clipboard->clipboard, "text/plain");
         guac_common_clipboard_append(clipboard->clipboard, received_data, length);
-        guac_common_clipboard_send(clipboard->clipboard, clipboard->client);
+        guac_common_clipboard_send(clipboard->clipboard, client);
     }
 
     return CHANNEL_RC_OK;
diff --git a/src/protocols/rdp/channels/common-svc.c b/src/protocols/rdp/channels/common-svc.c
index 8b076341..ce3bf8f2 100644
--- a/src/protocols/rdp/channels/common-svc.c
+++ b/src/protocols/rdp/channels/common-svc.c
@@ -89,12 +89,16 @@ void guac_rdp_common_svc_write(guac_rdp_common_svc* svc,
         return;
     }
 
+    guac_rdp_client* rdp_client = (guac_rdp_client*) svc->client->data;
+
     /* NOTE: The wStream sent via pVirtualChannelWriteEx will automatically be
      * freed later with a call to Stream_Free() when handling the
      * corresponding write cancel/completion event. */
+    pthread_mutex_lock(&(rdp_client->message_lock));
     svc->_entry_points.pVirtualChannelWriteEx(svc->_init_handle,
             svc->_open_handle, Stream_Buffer(output_stream),
             Stream_GetPosition(output_stream), output_stream);
+    pthread_mutex_unlock(&(rdp_client->message_lock));
 
 }
 
diff --git a/src/protocols/rdp/channels/disp.c b/src/protocols/rdp/channels/disp.c
index a25f6fa9..95dc6d99 100644
--- a/src/protocols/rdp/channels/disp.c
+++ b/src/protocols/rdp/channels/disp.c
@@ -31,9 +31,10 @@
 #include <stdlib.h>
 #include <string.h>
 
-guac_rdp_disp* guac_rdp_disp_alloc() {
+guac_rdp_disp* guac_rdp_disp_alloc(guac_client* client) {
 
     guac_rdp_disp* disp = malloc(sizeof(guac_rdp_disp));
+    disp->client = client;
 
     /* Not yet connected */
     disp->disp = NULL;
@@ -220,8 +221,17 @@ void guac_rdp_disp_update_size(guac_rdp_disp* disp,
         }};
 
         /* Send display update notification if display channel is connected */
-        if (disp->disp != NULL)
+        if (disp->disp != NULL) {
+
+            guac_client* client = disp->client;
+            guac_rdp_client* rdp_client = (guac_rdp_client*) client->data;
+
+            pthread_mutex_lock(&(rdp_client->message_lock));
             disp->disp->SendMonitorLayout(disp->disp, 1, monitors);
+            pthread_mutex_unlock(&(rdp_client->message_lock));
+
+        }
+
     }
 
 }
diff --git a/src/protocols/rdp/channels/disp.h b/src/protocols/rdp/channels/disp.h
index 2aff7c2d..4739c16c 100644
--- a/src/protocols/rdp/channels/disp.h
+++ b/src/protocols/rdp/channels/disp.h
@@ -48,6 +48,11 @@
  */
 typedef struct guac_rdp_disp {
 
+    /**
+     * The guac_client instance handling the relevant RDP connection.
+     */
+    guac_client* client;
+
     /**
      * Display control interface.
      */
@@ -81,10 +86,13 @@ typedef struct guac_rdp_disp {
  * Allocates a new display update module, which will ultimately control the
  * display update channel once connected.
  *
+ * @param client
+ *     The guac_client instance handling the relevant RDP connection.
+ *
  * @return
  *     A newly-allocated display update module.
  */
-guac_rdp_disp* guac_rdp_disp_alloc();
+guac_rdp_disp* guac_rdp_disp_alloc(guac_client* client);
 
 /**
  * Frees the resources associated with support for the RDP Display Update
diff --git a/src/protocols/rdp/channels/rail.c b/src/protocols/rdp/channels/rail.c
index 5f105c8e..6f8d7f7f 100644
--- a/src/protocols/rdp/channels/rail.c
+++ b/src/protocols/rdp/channels/rail.c
@@ -86,7 +86,10 @@ static UINT guac_rdp_rail_complete_handshake(RailClientContext* rail) {
     };
 
     /* Send client handshake response */
+    pthread_mutex_lock(&(rdp_client->message_lock));
     status = rail->ClientHandshake(rail, &handshake);
+    pthread_mutex_unlock(&(rdp_client->message_lock));
+
     if (status != CHANNEL_RC_OK)
         return status;
 
@@ -95,7 +98,10 @@ static UINT guac_rdp_rail_complete_handshake(RailClientContext* rail) {
     };
 
     /* Send client status */
+    pthread_mutex_lock(&(rdp_client->message_lock));
     status = rail->ClientInformation(rail, &client_status);
+    pthread_mutex_unlock(&(rdp_client->message_lock));
+
     if (status != CHANNEL_RC_OK)
         return status;
 
@@ -139,7 +145,10 @@ static UINT guac_rdp_rail_complete_handshake(RailClientContext* rail) {
     };
 
     /* Send client system parameters */
+    pthread_mutex_lock(&(rdp_client->message_lock));
     status = rail->ClientSystemParam(rail, &sysparam);
+    pthread_mutex_unlock(&(rdp_client->message_lock));
+
     if (status != CHANNEL_RC_OK)
         return status;
 
@@ -151,7 +160,11 @@ static UINT guac_rdp_rail_complete_handshake(RailClientContext* rail) {
     };
 
     /* Execute desired RemoteApp command */
-    return rail->ClientExecute(rail, &exec);
+    pthread_mutex_lock(&(rdp_client->message_lock));
+    status = rail->ClientExecute(rail, &exec);
+    pthread_mutex_unlock(&(rdp_client->message_lock));
+
+    return status;
 
 }
 
diff --git a/src/protocols/rdp/channels/rdpei.c b/src/protocols/rdp/channels/rdpei.c
index f1c5d09e..af1771d4 100644
--- a/src/protocols/rdp/channels/rdpei.c
+++ b/src/protocols/rdp/channels/rdpei.c
@@ -32,9 +32,10 @@
 #include <stdlib.h>
 #include <string.h>
 
-guac_rdp_rdpei* guac_rdp_rdpei_alloc() {
+guac_rdp_rdpei* guac_rdp_rdpei_alloc(guac_client* client) {
 
     guac_rdp_rdpei* rdpei = malloc(sizeof(guac_rdp_rdpei));
+    rdpei->client = client;
 
     /* Not yet connected */
     rdpei->rdpei = NULL;
@@ -107,6 +108,9 @@ void guac_rdp_rdpei_load_plugin(rdpContext* context) {
 int guac_rdp_rdpei_touch_update(guac_rdp_rdpei* rdpei, int id, int x, int y,
         double force) {
 
+    guac_client* client = rdpei->client;
+    guac_rdp_client* rdp_client = (guac_rdp_client*) client->data;
+
     int contact_id; /* Ignored */
 
     /* Track touches only if channel is connected */
@@ -149,20 +153,31 @@ int guac_rdp_rdpei_touch_update(guac_rdp_rdpei* rdpei, int id, int x, int y,
         if (!touch->active)
             return 1;
 
+        pthread_mutex_lock(&(rdp_client->message_lock));
         context->TouchEnd(context, id, x, y, &contact_id);
+        pthread_mutex_unlock(&(rdp_client->message_lock));
+
         touch->active = 0;
 
     }
 
     /* Signal the start of a touch if this is the first we've seen it */
     else if (!touch->active) {
+
+        pthread_mutex_lock(&(rdp_client->message_lock));
         context->TouchBegin(context, id, x, y, &contact_id);
+        pthread_mutex_unlock(&(rdp_client->message_lock));
+
         touch->active = 1;
+
     }
 
     /* Established touches need only be updated */
-    else
+    else {
+        pthread_mutex_lock(&(rdp_client->message_lock));
         context->TouchUpdate(context, id, x, y, &contact_id);
+        pthread_mutex_unlock(&(rdp_client->message_lock));
+    }
 
     return 0;
 
diff --git a/src/protocols/rdp/channels/rdpei.h b/src/protocols/rdp/channels/rdpei.h
index 5ca10c30..5b16d31a 100644
--- a/src/protocols/rdp/channels/rdpei.h
+++ b/src/protocols/rdp/channels/rdpei.h
@@ -66,6 +66,11 @@ typedef struct guac_rdp_rdpei_touch {
  */
 typedef struct guac_rdp_rdpei {
 
+    /**
+     * The guac_client instance handling the relevant RDP connection.
+     */
+    guac_client* client;
+
     /**
      * RDPEI control interface.
      */
@@ -83,10 +88,13 @@ typedef struct guac_rdp_rdpei {
  * channel once connected. The RDPEI channel allows multi-touch input
  * events to be sent to the RDP server.
  *
+ * @param client
+ *     The guac_client instance handling the relevant RDP connection.
+ *
  * @return
  *     A newly-allocated RDPEI module.
  */
-guac_rdp_rdpei* guac_rdp_rdpei_alloc();
+guac_rdp_rdpei* guac_rdp_rdpei_alloc(guac_client* client);
 
 /**
  * Frees the resources associated with support for the RDPEI channel. Only
diff --git a/src/protocols/rdp/client.c b/src/protocols/rdp/client.c
index 50808dcf..4d8171f5 100644
--- a/src/protocols/rdp/client.c
+++ b/src/protocols/rdp/client.c
@@ -145,10 +145,10 @@ int guac_client_init(guac_client* client, int argc, char** argv) {
     rdp_client->clipboard = guac_rdp_clipboard_alloc(client);
 
     /* Init display update module */
-    rdp_client->disp = guac_rdp_disp_alloc();
+    rdp_client->disp = guac_rdp_disp_alloc(client);
 
     /* Init multi-touch support module (RDPEI) */
-    rdp_client->rdpei = guac_rdp_rdpei_alloc();
+    rdp_client->rdpei = guac_rdp_rdpei_alloc(client);
 
     /* Redirect FreeRDP log messages to guac_client_log() */
     guac_rdp_redirect_wlog(client);
@@ -158,8 +158,9 @@ int guac_client_init(guac_client* client, int argc, char** argv) {
     pthread_mutexattr_settype(&(rdp_client->attributes),
             PTHREAD_MUTEX_RECURSIVE);
 
-    /* Initalize the lock */
+    /* Init required locks */
     pthread_rwlock_init(&(rdp_client->lock), NULL);
+    pthread_mutex_init(&(rdp_client->message_lock), &(rdp_client->attributes));
 
     /* Set handlers */
     client->join_handler = guac_rdp_user_join_handler;
@@ -226,6 +227,7 @@ int guac_rdp_client_free_handler(guac_client* client) {
         guac_rdp_audio_buffer_free(rdp_client->audio_input);
 
     pthread_rwlock_destroy(&(rdp_client->lock));
+    pthread_mutex_destroy(&(rdp_client->message_lock));
 
     /* Free client data */
     free(rdp_client);
diff --git a/src/protocols/rdp/input.c b/src/protocols/rdp/input.c
index 0c36d614..54e99f15 100644
--- a/src/protocols/rdp/input.c
+++ b/src/protocols/rdp/input.c
@@ -54,8 +54,11 @@ int guac_rdp_user_mouse_handler(guac_user* user, int x, int y, int mask) {
         guac_common_recording_report_mouse(rdp_client->recording, x, y, mask);
 
     /* If button mask unchanged, just send move event */
-    if (mask == rdp_client->mouse_button_mask)
+    if (mask == rdp_client->mouse_button_mask) {
+        pthread_mutex_lock(&(rdp_client->message_lock));
         rdp_inst->input->MouseEvent(rdp_inst->input, PTR_FLAGS_MOVE, x, y);
+        pthread_mutex_unlock(&(rdp_client->message_lock));
+    }
 
     /* Otherwise, send events describing button change */
     else {
@@ -75,7 +78,9 @@ int guac_rdp_user_mouse_handler(guac_user* user, int x, int y, int mask) {
             if (released_mask & 0x02) flags |= PTR_FLAGS_BUTTON3;
             if (released_mask & 0x04) flags |= PTR_FLAGS_BUTTON2;
 
+            pthread_mutex_lock(&(rdp_client->message_lock));
             rdp_inst->input->MouseEvent(rdp_inst->input, flags, x, y);
+            pthread_mutex_unlock(&(rdp_client->message_lock));
 
         }
 
@@ -91,7 +96,9 @@ int guac_rdp_user_mouse_handler(guac_user* user, int x, int y, int mask) {
             if (pressed_mask & 0x10) flags |= PTR_FLAGS_WHEEL | PTR_FLAGS_WHEEL_NEGATIVE | 0x88;
 
             /* Send event */
+            pthread_mutex_lock(&(rdp_client->message_lock));
             rdp_inst->input->MouseEvent(rdp_inst->input, flags, x, y);
+            pthread_mutex_unlock(&(rdp_client->message_lock));
 
         }
 
@@ -99,18 +106,18 @@ int guac_rdp_user_mouse_handler(guac_user* user, int x, int y, int mask) {
         if (pressed_mask & 0x18) {
 
             /* Down */
-            if (pressed_mask & 0x08)
-                rdp_inst->input->MouseEvent(
-                        rdp_inst->input,
-                        PTR_FLAGS_WHEEL | 0x78,
-                        x, y);
+            if (pressed_mask & 0x08) {
+                pthread_mutex_lock(&(rdp_client->message_lock));
+                rdp_inst->input->MouseEvent(rdp_inst->input, PTR_FLAGS_WHEEL | 0x78, x, y);
+                pthread_mutex_unlock(&(rdp_client->message_lock));
+            }
 
             /* Up */
-            if (pressed_mask & 0x10)
-                rdp_inst->input->MouseEvent(
-                        rdp_inst->input,
-                        PTR_FLAGS_WHEEL | PTR_FLAGS_WHEEL_NEGATIVE | 0x88,
-                        x, y);
+            if (pressed_mask & 0x10) {
+                pthread_mutex_lock(&(rdp_client->message_lock));
+                rdp_inst->input->MouseEvent(rdp_inst->input, PTR_FLAGS_WHEEL | PTR_FLAGS_WHEEL_NEGATIVE | 0x88, x, y);
+                pthread_mutex_unlock(&(rdp_client->message_lock));
+            }
 
         }
 
diff --git a/src/protocols/rdp/keyboard.c b/src/protocols/rdp/keyboard.c
index b027bde5..a8a6f8b7 100644
--- a/src/protocols/rdp/keyboard.c
+++ b/src/protocols/rdp/keyboard.c
@@ -104,8 +104,9 @@ static void guac_rdp_send_key_event(guac_rdp_client* rdp_client,
         return;
 
     /* Send actual key */
-    rdp_inst->input->KeyboardEvent(rdp_inst->input,
-            flags | pressed_flags, scancode);
+    pthread_mutex_lock(&(rdp_client->message_lock));
+    rdp_inst->input->KeyboardEvent(rdp_inst->input, flags | pressed_flags, scancode);
+    pthread_mutex_unlock(&(rdp_client->message_lock));
 
 }
 
@@ -132,9 +133,9 @@ static void guac_rdp_send_unicode_event(guac_rdp_client* rdp_client,
         return;
 
     /* Send Unicode event */
-    rdp_inst->input->UnicodeKeyboardEvent(
-            rdp_inst->input,
-            0, codepoint);
+    pthread_mutex_lock(&(rdp_client->message_lock));
+    rdp_inst->input->UnicodeKeyboardEvent(rdp_inst->input, 0, codepoint);
+    pthread_mutex_unlock(&(rdp_client->message_lock));
 
 }
 
@@ -161,7 +162,9 @@ static void guac_rdp_send_synchronize_event(guac_rdp_client* rdp_client,
         return;
 
     /* Synchronize lock key states */
+    pthread_mutex_lock(&(rdp_client->message_lock));
     rdp_inst->input->SynchronizeEvent(rdp_inst->input, flags);
+    pthread_mutex_unlock(&(rdp_client->message_lock));
 
 }
 
diff --git a/src/protocols/rdp/plugins/guacai/guacai-messages.c b/src/protocols/rdp/plugins/guacai/guacai-messages.c
index eb9a79da..48c828cb 100644
--- a/src/protocols/rdp/plugins/guacai/guacai-messages.c
+++ b/src/protocols/rdp/plugins/guacai/guacai-messages.c
@@ -247,6 +247,8 @@ static void guac_rdp_ai_send_formatchange(IWTSVirtualChannel* channel,
 void guac_rdp_ai_process_version(guac_client* client,
         IWTSVirtualChannel* channel, wStream* stream) {
 
+    guac_rdp_client* rdp_client = (guac_rdp_client*) client->data;
+
     /* Verify we have at least 4 bytes available (UINT32) */
     if (Stream_GetRemainingLength(stream) < 4) {
         guac_client_log(client, GUAC_LOG_WARNING, "Audio input Versoin PDU "
@@ -269,8 +271,9 @@ void guac_rdp_ai_process_version(guac_client* client,
     Stream_Write_UINT32(response, 1); /* Version */
 
     /* Send response */
-    channel->Write(channel, (UINT32) Stream_GetPosition(response),
-            Stream_Buffer(response), NULL);
+    pthread_mutex_lock(&(rdp_client->message_lock));
+    channel->Write(channel, (UINT32) Stream_GetPosition(response), Stream_Buffer(response), NULL);
+    pthread_mutex_unlock(&(rdp_client->message_lock));
     Stream_Free(response, TRUE);
 
 }
@@ -313,26 +316,34 @@ void guac_rdp_ai_process_formats(guac_client* client,
                 format.channels, format.bps / 8);
 
         /* Accept single format */
+        pthread_mutex_lock(&(rdp_client->message_lock));
         guac_rdp_ai_send_incoming_data(channel);
         guac_rdp_ai_send_formats(channel, &format, 1);
+        pthread_mutex_unlock(&(rdp_client->message_lock));
         return;
 
     }
 
     /* No formats available */
     guac_client_log(client, GUAC_LOG_WARNING, "AUDIO_INPUT: No WAVE format.");
+    pthread_mutex_lock(&(rdp_client->message_lock));
     guac_rdp_ai_send_incoming_data(channel);
     guac_rdp_ai_send_formats(channel, NULL, 0);
+    pthread_mutex_unlock(&(rdp_client->message_lock));
 
 }
 
-void guac_rdp_ai_flush_packet(char* buffer, int length, void* data) {
+void guac_rdp_ai_flush_packet(guac_rdp_audio_buffer* audio_buffer, int length) {
 
-    IWTSVirtualChannel* channel = (IWTSVirtualChannel*) data;
+    guac_client* client = audio_buffer->client;
+    guac_rdp_client* rdp_client = (guac_rdp_client*) client->data;
+    IWTSVirtualChannel* channel = (IWTSVirtualChannel*) audio_buffer->data;
 
     /* Send data over channel */
+    pthread_mutex_lock(&(rdp_client->message_lock));
     guac_rdp_ai_send_incoming_data(channel);
-    guac_rdp_ai_send_data(channel, buffer, length);
+    guac_rdp_ai_send_data(channel, audio_buffer->packet, length);
+    pthread_mutex_unlock(&(rdp_client->message_lock));
 
 }
 
@@ -363,8 +374,10 @@ void guac_rdp_ai_process_open(guac_client* client,
             audio_buffer->out_format.bps);
 
     /* Success */
+    pthread_mutex_lock(&(rdp_client->message_lock));
     guac_rdp_ai_send_formatchange(channel, initial_format);
     guac_rdp_ai_send_open_reply(channel, 0);
+    pthread_mutex_unlock(&(rdp_client->message_lock));
 
     /* Begin receiving audio data */
     guac_rdp_audio_buffer_begin(audio_buffer, packet_frames,
diff --git a/src/protocols/rdp/rdp.c b/src/protocols/rdp/rdp.c
index 66537156..1c528e66 100644
--- a/src/protocols/rdp/rdp.c
+++ b/src/protocols/rdp/rdp.c
@@ -107,7 +107,7 @@ BOOL rdp_freerdp_pre_connect(freerdp* instance) {
 
     /* Load "AUDIO_INPUT" plugin for audio input*/
     if (settings->enable_audio_input) {
-        rdp_client->audio_input = guac_rdp_audio_buffer_alloc();
+        rdp_client->audio_input = guac_rdp_audio_buffer_alloc(client);
         guac_rdp_audio_load_plugin(instance->context);
     }
 
@@ -564,13 +564,16 @@ static int guac_rdp_handle_connection(guac_client* client) {
                 guac_timestamp frame_end;
                 int frame_remaining;
 
-                /* Check the libfreerdp fds */
-                if (!freerdp_check_event_handles(rdp_inst->context)) {
+                /* Handle any queued FreeRDP events (this may result in RDP
+                 * messages being sent) */
+                pthread_mutex_lock(&(rdp_client->message_lock));
+                int event_result = freerdp_check_event_handles(rdp_inst->context);
+                pthread_mutex_unlock(&(rdp_client->message_lock));
 
-                    /* Flag connection failure */
+                /* Abort if FreeRDP event handling fails */
+                if (!event_result) {
                     wait_result = -1;
                     break;
-
                 }
 
                 /* Calculate time remaining in frame */
@@ -634,7 +637,9 @@ static int guac_rdp_handle_connection(guac_client* client) {
     }
 
     /* Disconnect client and channels */
+    pthread_mutex_lock(&(rdp_client->message_lock));
     freerdp_disconnect(rdp_inst);
+    pthread_mutex_unlock(&(rdp_client->message_lock));
 
     /* Clean up FreeRDP internal GDI implementation */
     gdi_free(rdp_inst);
diff --git a/src/protocols/rdp/rdp.h b/src/protocols/rdp/rdp.h
index cc537966..ab6c3c52 100644
--- a/src/protocols/rdp/rdp.h
+++ b/src/protocols/rdp/rdp.h
@@ -172,6 +172,12 @@ typedef struct guac_rdp_client {
      */
     pthread_rwlock_t lock;
 
+    /**
+     * Lock which synchronizes the sending of each RDP message, ensuring
+     * attempts to send RDP messages never overlap.
+     */
+    pthread_mutex_t message_lock;
+
 } guac_rdp_client;
 
 /**